“- Big Time Willie: Do you know how to spell pussy?
- Coleman 'Booger' Sykes: I know! P-U...
- Big Time Willie: ...H-I-V.”
Roger Guenveur Smith - Big Time Willie
Hill Harper - Coleman 'Booger' Sykes

“- Ste Pearce: You cannot transmit the HIV virus by frottage. What's frottage?
- Jamie Gangel: It's yogurt. It's French.”

Scott Neal - Ste Pearce
Glen Berry - Jamie Gangel

“If you caught gonorrhea, I'll kill you... I'm wearing too many clothes.”

Sean Young - Susan Atwell

“Listen. I don't care what you say. Chlamydia is a soup. It's my opinion. I can have that if I'd like. You don't have to argue. I've seen it on the grocery store shelf. Don't argue with me about it. I don't care if you are a doctor.”
Tim meadows - Leon Phelps

“- DiMucci: You got something going with Paulette?
- Nogerelli: Let's just say I'm giving her therapy for her disease.
- DiMucci: Which disease?
- Nogerelli: Nymphomania.”
Peter Frechette - DiMucci
Adrian Zmed - Nogerelli