“- Donnie Azoff: Jesus Christ, I think you have a fuckin' drug problem.
- Jordan Belfort: Where are the 'ludes'?
- Donnie Azoff: They're up my ass. Don't worry about it, I got it.
- Jordan Belfort: [sigh of relief] Thank God.”
Jonah Hill - Donnie Azoff
Leonardo DiCaprio - Jordan Belfort

“One bottle of Valium, which I've already procured from my mother, who is, in her own domestic and socially acceptable way also a drug addict.”
Ewan Gordon McGregor - Mark Renton

“I really am the luckiest guy in the world. Several years of addiction right in the middle of an epidemic, surrounded by the living dead. But not me. I'm negative. It's official. And once the pain goes away, that's when the real battle starts. Depression, boredom... you feel so fucking low, you want to fucking top yourself.”
Ewan Gordon McGregor - Mark Renton

“- Honey: How can you be a drug addict in the new millennium? It's so retro.
- Lyle: Before I was a drug addict, I had so many different problems. Now I just have one - drugs! Gave my life a real focus.”
Melanie Griffith - Honey Whitlock
Adrian Grenier - Lyle

“You know, booze isn't really your drug of choice anyway. You're addicted to chaos. For some of us, it's coke. For some of us, it's bourbon. But you? You got hooked on disaster.”

William Hurt - Doyle's Sponsor