“- Pacha: We're on our honeymoon.
- Waitress: Bless you for coming out in public..”

John Goodman - Patcha
Patti Deutsch - Waitress

“- James Griswold: I've never even heard of the original vacation.
- Rusty Griswold: Doesn't matter. The new vacation will stand on its own.”
Skyler Gisondo - James Griswold
Ed Helms - Rusty Griswold

“- J. Worthington Foulfellow: There is only one cure! A vacation! On Pleasure Island!
- Pinocchio: Pleasure Island?
- J. Worthington Foulfellow: Yes! That happy land of carefree boys where everyday's a holiday!”

Walter Catlett - J. Worthington Foulfellow
Dickie Jones - Pinocchio

“Boys, the honeymoon's over. From now on you're marines.”
William Bendix - Pvt. Aloysius K. "Smacksie" Randall

“- Diane: I am going on vacation this weekend. Remember?
- Wayne: Of course I remem... I forgot.
- Diane: I am going on this vacation and nothing and nobody is going to stop me!
- Wayne: Boy, she does need a vacation.”
Eve Gordon - Diane
Rick Moranis - Wayne