“- Charisse Dolittle: What am I supposed to do without my cell phone?
- Dr. John Dolittle: Here's some stamps. Learn how to write a letter or something.”
Raven-Symoné - Charisse Dolittle
Eddie Murphy - Dr. John Dolittle

“- Pelagia: I wrote to you every day. A hundred letters... and not a single reply.
- Mandras: I never learned... to read or write.”
Penelope Cruz - Pelagia
Christian Bale - Mandras

- Paul Vitti: Jelly, did they find that note?
- Jelly: No, but they will in a minute.
- Dr. Ben Sobel: Oh, and let me guess what it says? "Life is bullshit, I can't fucking take it no more! Signed, the Dead Guy".
- Jelly: That's good, Doc.

Robert De Niro - Paul Vitti
Joe Viterelli - Jelly
Billy Crystal - Dr. Ben Sobel

“- Young Celie Harris: Write!
- Nettie Harris: What?
- Young Celie Harris: Write!
- Nettie Harris: Nothing but death can keep me from it!”
Desreta Jackson - Young Celie Harris
Akosua Busia - Nettie Harris

“- Dr. Donald Shirley: What on God's green earth are you doing?
- Tony Lip: A letter.
- Dr. Donald Shirley: Looks more like a piecemeal ransom note.”
Mahershala Ali - Dr. Donald Shirley
Viggo Mortensen - Tony Lip