“- Lady Eboshi: Stay here. Help me kill the Forest Spirit, Ashitaka.
- Ashitaka: You would do that? Kill the very heart of the forest?
- Lady Eboshi: Without that ancient god, the animals here would be nothing but dumb beasts once again.”
Minnie Driver - Lady Eboshi
Billy Crudup - Ashitaka

“You know how my mom can communicate with animals? Apparently they don't like being eaten.”
Danielle Panabaker - Layla

“- Bert: I'm gonna go shoot some squirrels.
- Paul: Why would you wanna kill squirrels?
- Bert: 'cause they're gay... I'm kidding. I don't care if they're gay or straight, I'll kill 'em either way.”
James DeBello - Bert
Rider Strong - Paul

“- Kathryn Morgan: Our shark couldn't have killed Overman. Its mother did.
- Calvin Bouchard: You're talkin' about some damn shark's mother?”
Bess Armstrong - Dr. Kathryn 'Kay' Morgan
Louis Gossett Jr. - Calvin Bouchard

“White sharks are dangerous. I know 'em. My father, my brother, myself. They're murderers.”
Dennis Quaid - Mike Brody