“- Bobo: You're the one who's fat!
- L'il Debbull: Not as fat as you!”
Dan Aykroyd - Bobo
John Daveikis - L'il Debbull

“- Dutch Dooley: Doyle, switch cots with me, mine won't hold me.
- Doyle Standish : How do you know it'll hold me?
- Dutch Dooley: Because I'm 15,000 cheeseburgers ahead of you in life.”
Ed O'Neill - Dutch Dooley
Ethan Embry - Doyle Standish

“- Amber Von Tussle: Aren't you a little fat for the show?
- Tracy Turnblad: I'm sure many of the other home viewers out there are pleasantly plump or chunky.
- Amber Von Tussle: Come on. The show's not filmed in Cinemascope.”
Vitamin C - Amber von Tussle
Ricki Lake - Tracy Turnblad

“- Walter Fielding: Has this ever happened to you before?
- Jack Schnittman: Yes.
- Paramedic: Seven times in the past five months.
- Walter Fielding: I thought the jogging was getting you in better shape.
- Jack Schnittman: It is.
- Paramedic: Yeah thanks to the jogging I can lift him into the ambulance.”

Tom Hanks - Walter Fielding
Josh Mostel - Jack Schnittman
Wendell Pierce - Paramedic

“Keep cooking like that and I won't even be able to move, let alone do science.”

Larry Blamire - Dr. Paul Armstrong