“He has this disease where his head is shaved except he doesn't have to shave it because he can't grow any hair in the first place. Don't talk about it around him though. It might offend him.”
Owen Wilson - Francis

“Brendan-Why are your eyes so red?
Francis-Why is your head so bald?”
Owen Wilson - Francis
Wallace Wolodarsky - Brendan

Don't anyone say "April Fool's" again or I'll rip them apart!
Amy Steel - Kit

“- Chaz: Why don't you tell us something about yourself?
- Nikki: All right, something about myself... I wanna work with handicapped children, and my parents are my best friends. And I start convent school next semester... and I fuck on the first date. April Fool's!”
Clayton Rohner - Chaz
Deborah Goodrich - Nikki

- Sandy Bates: I gotta give my one classical-music joke which I put in every single picture and I invariably cut it out.
- Daisy: Yeah?
- Sandy Bates: Um, uh... "I don't know much about classic music. For years I thought the Goldberg Variations were something Mr. and Mrs. Goldberg tried on their wedding night".
Woody Allen - Sandy Bates
Jessica Harper - Daisy