“- Steff: C'mon, I'm talking about more than just sex here.
- Andie: No, you're not.
- Steff: You know, I've been out with a lot of girls at this school. I don't see what makes you so different.”
James Spader - Steff
Molly Ringwald - Andie

“- Buck Laughlin: Tell me, do you know the difference between a rectal thermometer and a tongue depressor?
- Leslie's Nurse: Uh, no.
- Buck Laughlin: Remind me never to come to you for a physical!”
Fred Willard - Buck Laughlin
Jay-Lyn Green - Leslie's Nurse

“- Mike: What the fuck are you carrying a gun for? What, in case somebody steps to you, Snoop Dogg?
- Sue: Hey man, you're not from here, alright. You don't know how it is. I grew up in L.A.
- Trent: Anaheim.
- Sue: Whatever, man. It's different out here. It's not like New York, Mikey.”
Jon Favreau - Mike
Patrick Van Horn - Sue
Vince Vaughn - Trent

“I don't know what they taught you in France, but 'rude' and 'interesting' are not the same things.”
Meg Ryan - Kate

“- Romy White: Didn't you have a thing for Sandy in high school?
- Heather Mooney: I did not have a thing! I did not have a thing, I did not have a thing! I was very much in love with him! Very much in love and there's a difference!”
Mira Sorvino - Romy White
Janeane Garofalo - Heather Mooney