“- Dr. John Dolittle: It's not something you should be ashamed of. It happens to most men occasionally. You're probably under a lot of pressure.
- Female Pigeon: He's not under pressure. He's not attracted to me, because I'm just a pigeon. He's a self-hating pigeon.”

Eddie Murphy - Dr. John Dolittle
Julie Kavner - Female Pigeon

“- Maddy Whittier: You're really different than I thought you're gonna be.
- Olly Bright: Sexier, right?”
Amandla Stenberg - Maddy
Nick Robinson - Olly

“Do I scare you? People are either drawn to me, or they pretend like they can't see me. It's a trip. They think because I'm close to the other side, I got some sort of power or wisdom.”
James Badge Dale - Gaunt Young Man

“- Jane Lindquist: We're not reality material.
- Joe MacGonaughgill: I didn't know that.
- Jane Lindquist: What's a cute... smart, sexy, good-looking guy... Why haven't you slept with a girl for the last five years?
- Joe MacGonaughgill: I've been saving myself.”
Elle Macpherson - Jane Lindquist
Eric Schaeffer - Joe MacGonaughgill

“- Bruce Baldwin: I like him; he's got a lot of charm.
- Hildy Johnson: Well he comes by it naturally, his grandfather was a snake.”

Ralph Bellamy - Bruce Baldwin
Rosalind Russell - Hildy Johnson